Enhancement of intranasal mucosal immunization of mucosal vaccines by ultrasonic treatment

Recombinant probiotic-Based Vaccines; Attractive vehicles for immunization via mucosal routes

Introduction: The importance of genetically modified microorganisms, including probiotics, now widely have considered as attractive vehicles for mucosal delivery of therapeutic molecules. Previous studies have indicated that mucosal administration of these molecules can effectively trigger humoral along with cellular immune responses. Therefore, development of induction of mucosal immune respon...

Mucosal immunization

Increased immunization coverage, along with improved sanitization and safe water, is the most important public health intervention to improve child health in documented human history, resulting in a significant decrease in child mortality during the 20 century. Immunization is considered by the World Health Organization (WHO) as one of the most cost-effective of all health interventions, having...

Mucosal Immunity and Vaccines

These mucosal surfaces, while located inside the body, are actually a physical barrier between the outside and the sterile interior cavity of the body known as the “systemic” environment. Critical nutrients, oxygen and other molecules are constantly taken up across these mucosal barriers; however, another important function of the mucous is to keep invading pathogens out [15]. Daily these mucou...

Mucosal Tolerance a Barrier? Perspectives on Mucosal Vaccines: Is

Mucosal immunization: a realistic alternative.

Most infections occur at or through mucosal surfaces. Despite this knowledge, current vaccination practices rely predominantly on parenteral administration with only a few vaccines being registered for administion by the mucosal route. Whilst mucosal immunization brings many advantages, the lack of reliable delivery systems has been a major drawback to date. With the recent advances in delivery...